Compare azithromycin vs. Clindesse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zithromax (azithromycin)

Prescription only

Clindesse (clindamycin)

Prescription only
Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

4.0/ 5 average rating with 909 reviewsforazithromycin
Treats bacterial vaginal infections with a single dose.

Clindesse (clindamycin) treats vaginal infections and is very easy to use.

Upsides
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • Very easy to use and works within a few days.
  • Generic available, so cost is lower.
  • Doesn't have many side effects.
  • You can stand up and walk around right after you use it, so you can use it at any time of day.
Downsides
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • Can cause yeast infections in some women.
  • After using Clindesse (clindamycin), must avoid sex and using tampons for 7 days.
  • Can very rarely cause severe diarrhea.
  • Cannot be used if you have bowel diseases like Crohn's disease or ulcerative colitis.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Extended-release liquid
  • Cream
Price
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Reviews
909 reviews so far
74%
saidit'sworth it
59%
saiditworked well
11%
saidit'sa big hassle

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Side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
5possible side effects
  • Yeast infection
    14%
  • Headache
    7%
  • Back pain
    5%
  • Constipation
    2%
  • Bladder infection
    2%
See more detailed side effects
Risks and risk factors
  • Diarrhea caused by bacteria (Clostridium difficile)
  • Liver damage
    • History of liver disease
  • Myasthenia gravis
    • Myasthenia gravis
  • Serious allergic reaction
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
    • Elderly
See more detailed risks and warnings
  • Allergy alert
    • Known allergy to clindamycin
    • Known allergy to lincosamides
  • Severe diarrhea
    • History of Clostridium difficile-associated diarrhea
    • Crohn's disease
    • Ulcerative colitis
    • Regional enteritis
  • Weakened condoms and vaginal diaphragms
  • Safety in girls who haven't started puberty
See more detailed risks and warnings