Compare azithromycin vs. minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zithromax (azithromycin)

Prescription only

Solodyn (minocycline)

Prescription only
Treats bacterial infections.

Zithromax (azithromycin) is good for treating many bacterial infections and is available in generic form. However, it may cause headache, dizziness, or rash.

4.0/ 5 average rating with 909 reviewsforazithromycin
Treats bacterial infections.

Solodyn (minocycline) is effective in treating a variety of bacterial infections such as acne, but it can cause permanent tooth staining, especially in an unborn baby and those who are age 8 or younger.

4.0/ 5 average rating with 17 reviewsforminocycline
Upsides
  • Available as a generic in the tablet and suspension form.
  • The suspension can be used if you have problems swallowing.
  • Used to treat many types of bacterial infections.
  • Bacteria is less resistant to this antibiotic, meaning that Zithromax (azithromycin) will fight off the bacteria better. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Immediate release form can be taken with or without food.
  • May be taken with or without food.
  • Solodyn (minocycline) is used in combination with other medications to treat severe acne.
  • Available as a generic form.
  • Solodyn (minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Can be a good alternative treatment for certain infections when penicillin can't be used.
Downsides
  • Must space out antacids by at least 2 hours.
  • Use with caution if you have liver disease.
  • Must be used with caution if you are on medications to thin the blood (anticoagulants) because of increased risk of bleeding.
  • It can make birth control pills less effective, so barrier methods of birth control like condoms or diaphragms should be used while on Solodyn (minocycline).
  • Can permanently discolor your teeth, mouth, gums and skin. This is more common for pregnant women in their last half of pregnancy, infants, and children 8 and younger.
  • Your skin may be more sensitive to the sun and your chances of getting sunburned are higher.
  • May cause dizziness and affect your driving ability.
  • Not a good option for pregnant women since it can slow down the bone development of a fetus (unborn baby).
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Used for
Dosage forms
  • Pill
  • Liquid
  • Extended-release liquid
  • Pill
  • Extended-release pill
Price
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Reviews
909 reviews so far
74%
saidit'sworth it
59%
saiditworked well
11%
saidit'sa big hassle

Have you used Zithromax (azithromycin)?

Leave a review
17 reviews so far
53%
saidit'sworth it
59%
saiditworked well
18%
saidit'sa big hassle

Have you used Solodyn (minocycline)?

Leave a review
Side effects
3possible side effects
  • Vomiting
    5%
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Solodyn (minocycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Diarrhea caused by bacteria (Clostridium difficile)
  • Liver damage
    • History of liver disease
  • Myasthenia gravis
    • Myasthenia gravis
  • Serious allergic reaction
  • Abnormal heartbeat
    • QT prolongation
    • Arrhythmia
    • Drugs that cause prolonged QT interval
    • Abnormal electrolytes
    • Elderly
See more detailed risks and warnings
  • Yellowing of teeth
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
    • Using Solodyn (minocycline) for a long period of time
  • Decreased effectiveness of oral birth control pills
    • Using oral birth control pills
  • New infection
    • Using Solodyn (minocycline) for a long period of time
  • Sunburn
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings