Compare baclofen vs. Dantrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Lioresal (baclofen)

Prescription only

Dantrium (dantrolene)

Prescription only
Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Relaxes your muscles.

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
Used for
  • Malignant hyperthermia
  • Chronic spasticity
  • Neuroleptic malignant syndrome
Dosage forms
  • Pill
  • Pill
  • Injection
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33 reviews so far
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saiditworked well
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Side effects
1possible side effects
  • Drowsiness
See more detailed side effects
The Dantrium (dantrolene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings
  • Liver injury
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction
  • Drowsiness and dizziness
    • Alcohol or recreational drug use
  • Sun sensitivity
  • Lung disease
    • COPD
    • Heart failure
See more detailed risks and warnings