Compare baclofen vs. Detrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Lioresal (baclofen)

Prescription only

Detrol (tolterodine)

Prescription only
Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Treats overactive bladder.

Detrol (tolterodine) is a good treatment for overactive bladder after exercises and other methods to control it haven't worked.

  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Detrol (tolterodine) is effective at treating overactive bladder by lowering the urge to urinate, and controlling urination.
  • The tablet is available as a generic in both extended and immediate release, so you can take it once or twice a day.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
  • Detrol (tolterodine) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
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33 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
1possible side effects
  • Drowsiness
See more detailed side effects
10possible side effects
  • Dry mouth
  • Headache
  • Constipation
  • Stomach pain
  • Indigestion
  • Dry eyes
  • Sleepiness
  • Tiredness
  • Dizziness
  • Flu-like symptoms
See more detailed side effects
Risks and risk factors
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings
  • Face, lips, neck or throat swelling
  • Dizziness and drowsiness
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • People age 65 or older
  • Vision changes
    • Glaucoma
  • Trouble urinating & stomach problems
    • History of bladder problems
    • History of stomach or intestine problems
  • Heartbeat problems
    • History of heartbeat problems
    • Taking medicines to conrol heartbeat
  • Liver and Kidney problems
    • History of liver problems
    • History of Kidney problems
See more detailed risks and warnings