Compare baclofen vs. oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lioresal (baclofen)

Prescription only

Ditropan (oxybutynin)

Prescription or OTC
Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

3.5/ 5 average rating with 33 reviewsforbaclofen
Treats overactive bladder.

Ditropan (oxybutynin) is good treatment for overactive bladder, but has more side-effects like dry mouth and constipation than other medicines that work similarly.

Upsides
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
  • Available in several different formulations (pill, liquid, gel, patch) that help fit individual preferences.
  • The pill form is available in a cheap, generic version.
  • Works just as well as newer medications on the market in managing symptoms of an overactive bladder.
  • The patch form causes less side effects than the other forms of Ditropan (oxybutynin).
Downsides
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
  • Raises the risk of falls, especially in older people.
  • Ditropan (oxybutynin) may not be a good treatment option if you also have narrow-angle glaucoma.
  • Causes more side effects like dry mouth than newer medications used for treating overactive bladder.
  • Older people who use Ditropan (oxybutynin) are at higher risk of experiencing memory problems as well as side effects such as confusion and blurry vision.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended-release pill
  • Liquid
  • Patch
  • Gel
Price
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Reviews
33 reviews so far
61%
saidit'sworth it
55%
saiditworked well
15%
saidit'sa big hassle

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Side effects
1possible side effects
  • Drowsiness
    63%
See more detailed side effects
17possible side effects
  • Dry mouth
    35%
  • Constipation
    9%
  • Headache
    8%
  • Diarrhea
    8%
  • Insomnia
    6%
  • Drowsiness
    6%
  • Dizziness
    5%
  • Upset stomach
    5%
  • Nausea
    5%
  • Blurry vision
    4%
  • Dry eyes
    3%
  • Fatigue
    3%
  • Taste changes
    2%
  • Cough
    2%
  • Dry throat
    2%
  • Dry nose
    2%
  • Inability to urinate
    2%
See more detailed side effects
Risks and risk factors
  • Withdrawal symptoms
    • Stopping Lioresal (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings
  • Drowsiness and confusion
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Vision changes
    • Glaucoma
  • Trouble urinating
    • History of bladder problems
    • History of problems with your intestine
    • Taking more than one medicine for overactive bladder or taking allergy medicines
  • More side effects
    • Taking high doses
    • Age over 65 years
  • Heat exhaustion
    • Outside in hot weather
    • Dehydrated
    • Exercising
See more detailed risks and warnings