Compare Baraclude vs. Epivir

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis B.

Baraclude (entecavir) works well to treat hepatitis B, but tenofovir (Viread or Vemlidy) might be the better choice if you’ve taken other oral medicines for hepatitis B before or also have HIV.

Works with other medicines to treat HIV infection or chronic hepatitis B.

Epivir (lamivudine) is a first-choice and commonly used medicine to take together with other HIV medications to treat HIV. It is also an alternative option for treating chronic hepatitis B.

Upsides
  • Baraclude (entecavir) is a first-choice medicine to treat hepatitis B.
  • Safer option for people with kidney damage.
  • Side effects are mild and short-lived.
  • Can be used in children as young as 2 years old.
  • Conveniently comes as a liquid for children and people who struggle to swallow pills.
  • Epivir (lamivudine) can be used with many other HIV options to create a combination that's right for you.
  • Has very minimal interactions with other medications.
  • Available in tablet and liquid form.
  • Can be take once or twice a day. Also available in different combination pills so you don't have to take as many pills per day.
  • Available in cheaper generic form.
Downsides
  • Doesn't cure hepatitis B.
  • Might not be a good choice for people who’ve taken Epivir HBV (lamivudine) in the past due to the possibility of resistance.
  • Not the first choice for people with both hepatitis B and HIV.
  • Cannot take Epivir (lamivudine) by itself to treat HIV.
  • Might need to change dosage based on how well your kidneys function.
  • It is recommended to use other options to treat chronic hepatitis B before choosing Epivir (lamivudine) due to drug resistance.
  • You'll have to be tested for both HIV and hepatitis B, since the dose to treat hepatitis B is lower than the dose for HIV. If you have the lower dose, HIV can be harder to treat if you also have hepatitis B.
  • The liquid version of Epivir (lamivudine) has sugar, so if you have diabetes, your blood sugar levels might change.
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Used for
  • Hepatitis B
  • Prevention of hepatitis B reinfection after liver transplant
  • HIV infection
  • Hepatitis B
  • HIV prevention, non-occupational (PEP)
  • HIV prevention, mother-to-child
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
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Side effects
2possible side effects
  • Headache
    4%
  • Tiredness
    3%
See more detailed side effects
3possible side effects
  • Ear, nose, and throat infections
    25%
  • Diarrhea
    14%
  • Sore throat
    13%
See more detailed side effects
Risks and risk factors
  • Worsening of hepatitis B infection
    • Stopping Baraclude (entecavir)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Buildup of acid in the blood and swollen, fatty liver
    • Obesity
    • History of liver disease
    • Women
    • Taking Baraclude (entecavir) for a long time
See more detailed risks and warnings
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Acute Exacerbation of Hepatitis B Virus (HBV)
    • Hepatitis B virus
  • Different doses available
  • HIV counseling/testing
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Pancreatitis
See more detailed risks and warnings