Compare Baraclude vs. Vemlidy

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis B.

Baraclude (entecavir) works well to treat hepatitis B, but tenofovir (Viread or Vemlidy) might be the better choice if you’ve taken other oral medicines for hepatitis B before or also have HIV.

Treats hepatitis B virus (HBV) infections.

Vemlidy (tenofovir alafenamide) decreases liver damage from hepatitis B virus (HBV) and has minimal side effects, but doesn't cure the infection.

Upsides
  • Baraclude (entecavir) is a first-choice medicine to treat hepatitis B.
  • Safer option for people with kidney damage.
  • Side effects are mild and short-lived.
  • Can be used in children as young as 2 years old.
  • Conveniently comes as a liquid for children and people who struggle to swallow pills.
  • Vemlidy (tenofovir alafenamide) is a first-choice medicine to treat hepatitis B.
  • Conveniently taken once daily.
  • Compared to Truvada and Viread (tenofovir disoproxil fumarate), Vemlidy (tenofovir alafenamide) is safer for your kidneys and bones.
Downsides
  • Doesn't cure hepatitis B.
  • Might not be a good choice for people who’ve taken Epivir HBV (lamivudine) in the past due to the possibility of resistance.
  • Not the first choice for people with both hepatitis B and HIV.
  • Might not be the best choice for people with severe kidney damage.
  • There's not enough evidence to show that Vemlidy (tenofovir alafenamide) can be used safely in children ages 18 or younger.
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Used for
  • Hepatitis B
  • Prevention of hepatitis B reinfection after liver transplant
  • Hepatitis B treatment
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
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Side effects
2possible side effects
  • Headache
    4%
  • Tiredness
    3%
See more detailed side effects
6possible side effects
  • Headache
    9%
  • Stomach pain
    7%
  • Tiredness
    6%
  • Cough
    6%
  • Nausea
    5%
  • Back pain
    5%
See more detailed side effects
Risks and risk factors
  • Worsening of hepatitis B infection
    • Stopping Baraclude (entecavir)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Buildup of acid in the blood and swollen, fatty liver
    • Obesity
    • History of liver disease
    • Women
    • Taking Baraclude (entecavir) for a long time
See more detailed risks and warnings
  • Worsening of hepatitis B infection
    • Stopping Vemlidy (tenofovir alafenamide)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Kidney damage
    • Poor kidney function
    • Taking other medicines that can damage the kidneys
  • Buildup of acid in the blood and swollen, fatty liver
  • Lowered bone mineral density
    • Long-term use of Vemlidy (tenofovir alafenamide)
    • Use of other medications that result in loss of electrolytes or minerals
See more detailed risks and warnings