Compare Belsomra vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Belsomra (suvorexant)

Prescription only

Zonalon (Doxepin)

Prescription only
Helps you sleep.

Belsomra (suvorexant) helps you fall asleep, but is only avaliable as a brand name so can be expensive.

Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • May be helpful if other sleep aids don't work.
  • Works quickly, especially on an empty stomach.
  • Might be a good option for the elderly.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Not usually used for long-term treatment since it can be habit-forming.
  • Belsomra (suvorexant) is likely expensive since it's only available as a brand name, but coupon savings program could be available.
  • Not recommended if you do not plan to sleep for at least 7 hours.
  • Belsomra (suvorexant) may cause sleep paralysis.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
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Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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Reviews
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Side effects
8possible side effects
  • Headache
    7%
  • Sleepiness
    7%
  • Dizziness
    3%
  • Diarrhea
    2%
  • Dry mouth
    2%
  • Cold and flu
    2%
  • Abnormal dreams
    2%
  • Cough
    2%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Changes in thoughts
    • Uncontrolled psychiatric conditions
    • Alcohol
    • Other medicines that make you sleepy or dizzy
  • Hangover effect
    • Alcohol
    • Taking other medicines that make you less alert
    • Less than 7 hours of sleep after taking Belsomra (suvorexant)
  • Dependence and withdrawal
    • Continuous use for 2 weeks or more
  • Depression
    • Risk increases with dose
    • Past history of depression
  • Difficulty breathing
    • Sleep apnea
    • COPD
  • Sleep paralysis
See more detailed risks and warnings