Compare Benadryl vs. Mucinex
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.
Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.
- Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
- It can provide quick relief of allergy symptoms for both kids and adults.
- It makes you sleepy, so it'll help if your allergies are bothering you at night.
- The effects wear off in 4 to 6 hours, so side effects don't last that long.
- It comes as a tablet, capsule, liquid, and quick dissolving tablet.
- Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
- Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
- It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
- Available in liquid and tablet forms.
- Mucinex (Guaifenesin) is alcohol- and sugar-free.
- Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
- You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
- Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
- It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
- Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
- Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
- You need to drink a lot of fluids while taking this medication or it won't work as well.
- Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
- Can cause nausea, headache, and an upset stomach.
- Oral solution
- Cream, gel, or ointment
- Extended release
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- Using other drugs with the same ingredients
- Increased side effects
- Age 65 years or older
- Driving impairment
- Taking with alcohol
- Taking other medicines that make you less alert
- Children age 6 years and younger
- Trouble urinating
- Enlarged prostate
- History of bladder problems
- Vision changes
- Nursing mothers
- Nausea and vomiting