Compare Benicar vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Benicar (olmesartan)

Prescription only
Lowers blood pressure.

Benicar (olmesartan) is a good blood pressure-lowering medicine that protects your kidneys, but with fewer side effects.

3.9/ 5 average rating with 118 reviewsforBenicar
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

3.3/ 5 average rating with 139 reviewsforhydrochlorothiazide
Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Similar to ACE inhibitors (like lisinopril), with fewer side effects like cough and swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Available by itself and in combination with different blood pressure medicines in a single pill.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides
  • Requires regular blood tests to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Recently became a generic, though still relatively expensive.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
118 reviews so far
65%
saidit'sworth it
63%
saiditworked well
12%
saidit'sa big hassle

Have you used Benicar (olmesartan)?

Leave a review
139 reviews so far
47%
saidit'sworth it
31%
saiditworked well
16%
saidit'sa big hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
Side effects
1possible side effects
  • Dizziness
    3%
See more detailed side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Birth defects
    • Women of childbearing age
  • Worsening kidney problems
    • History of kidney problems
  • Swelling in the face and head
    • African descent
  • High potassium levels
    • Current kidney problems
    • Using medicines that increase potassium
    • Using salt substitutes
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Severe diarrhea
See more detailed risks and warnings
  • Dehydration and electrolyte imbalance
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
  • Severe allergic reactions
    • History of sulfa allergies
  • Gout
    • History of gout
    • Current kidney problems
  • Vision problems
    • History of sulfa or penicillin allergies
  • Higher blood sugars
    • Diabetes
See more detailed risks and warnings