Compare Benzamycin vs. Epiduo

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Topical treatment for acne and pimples.

Benzamycin (benzoyl peroxide / erythromycin) is a common affordable treatment for acne and pimples, but it can stain clothing and hair.

3.4/ 5 average rating with 146 reviewsforBenzamycin
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  • The combination of medicines in Benzamycin (benzoyl peroxide / erythromycin) works better to reduce bacteria in oil glands and improve overall appearance of acne than either medicine alone.
  • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin (benzoyl peroxide / erythromycin) not working as well over time (known as resistance).
  • Can be used in combination with acne pill medicine if your doctor thinks you need it.
  • A generic form of Benzamycin (benzoyl peroxide / erythromycin) is available to help lower cost.
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  • Benzamycin (benzoyl peroxide / erythromycin) may not work for everyone. Like with any acne medicine, you may have to try different medicines before finding the one that works for you.
  • You have to apply this twice a day. With some other medicines, you may only need to apply once a day.
  • Is generally only effective for mild to moderate acne. If you have severe acne, you may need an oral medication.
  • The most common form of Benzamycin (benzoyl peroxide / erythromycin) needs to be stored in the fridge and is only good for 3 months even if you have medicine remaining in the container.
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Used for
  • Acne vulgaris
Dosage forms
  • Gel
  • Cream, gel, or ointment
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146 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
6possible side effects
  • Dry skin
  • Dryness
  • Hives
  • Reaction where applied
  • Eyelid inflammation
  • Itching
See more detailed side effects
The Epiduo (Adapalene / Benzoyl Peroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Bleaching effects
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Allergic reaction
  • Development of more serious infections
    • Long-term use of Benzamycin (benzoyl peroxide / erythromycin)
  • Pregnancy and breastfeeding
See more detailed risks and warnings
No information currently available