Compare Boniva vs. Estrace

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Boniva (ibandronate)

Prescription only

Estrace (Estradiol)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

2.9/ 5 average rating with 64 reviewsforBoniva
Relieves hot flashes and vaginal symptoms related to menopause.

Estrace (Estradiol) treats symptoms of menopause, but causes more of side effects than other medicines like it.

Upsides
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Estrace (Estradiol) comes as a pill and is much easier to use compared to the cream form.
  • Available as a cheaper, generic version.
  • Usually you only need to take DRUG NAME for a short amount of time.
Downsides
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Associated with a higher risk for side effects like blood clots, stroke, and cancer compared to its cream formulation.
  • DRUG_ NAME can increase the risk of memory loss for women age 65 or older.
  • Your doctor might frequently change your dose of the medicine in the beginning until your symptoms are well-controlled.
  • Not recommended for women who need treatment only for vaginal dryness and itching.
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Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
  • Advanced prostate cancer
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
64 reviews so far
31%
saidit'sworth it
20%
saiditworked well
27%
saidit'sa big hassle

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Side effects
22possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
  • Cold
    4%
  • Localized joint stiffness and pain
    3%
  • Bronchitis
    3%
  • Headache
    3%
  • Influenza-like illness
    3%
  • Muscle pain
    2%
  • Muscle cramp
    2%
  • Urinary tract infection
    2%
  • Upper respiratory tract infection
    2%
  • Dizziness
    2%
  • Rash
    2%
  • Sleep difficulty
    2%
See more detailed side effects
The Estrace (Estradiol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings