Compare Boniva vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Boniva (ibandronate)

Prescription only

Evista (raloxifene)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

2.9/ 5 average rating with 64 reviewsforBoniva
Prevents bone loss and lowers your risk of invasive breast cancer.

Evista (raloxifene) helps to reduce bone loss and lower the risk of breast cancer in post-menopausal women, but it can cause blood clots.

Upsides
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Evista (raloxifene) is a good choice for prevention of bone loss for postmenopausal women. Evista (raloxifene) can also reduce your risk for invasive breast cancer.
  • Unlike bisphosphonates, Evista (raloxifene) is easier on your stomach.
  • Although Evista (raloxifene) acts like estrogen, it doesn't increase the chances of uterine or breast cancer.
  • If you are having hot flashes, Evista (raloxifene) may help relieve them, unlike some alternatives.
Downsides
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Evista (raloxifene) can cause side effects similar to estrogen such as clots and hot flashes, which doesn't happen with bisphosphonate alternatives like Fosamax (alendronate).
  • Premenopausal women cannot take Evista (raloxifene) for breast cancer prevention.
  • It is not the first choice treatment for osteoporosis unless you cannot take bisphosphonates.
  • Your doctor may ask you to take this medicine for years to prevent bone loss.
  • If you are on a blood-thinner called warfarin, you may need to do a blood test before starting this medicine.
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Used for
  • Post-menopausal osteoporosis
  • Breast cancer prevention
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
64 reviews so far
31%
saidit'sworth it
20%
saiditworked well
27%
saidit'sa big hassle

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Side effects
22possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
  • Cold
    4%
  • Localized joint stiffness and pain
    3%
  • Bronchitis
    3%
  • Headache
    3%
  • Influenza-like illness
    3%
  • Muscle pain
    2%
  • Muscle cramp
    2%
  • Urinary tract infection
    2%
  • Upper respiratory tract infection
    2%
  • Dizziness
    2%
  • Rash
    2%
  • Sleep difficulty
    2%
See more detailed side effects
45possible side effects
  • Hot flashes
    25%
  • Joint pain
    16%
  • Flu-like symptoms
    15%
  • Infection
    11%
  • Stuffy nose
    10%
  • Difficulty breathing
    10%
  • Sinus infection
    10%
  • Headache
    9%
  • Increased cough
    9%
  • Nausea
    9%
  • Weight gain
    9%
  • Muscle pain
    8%
  • Sore throat
    8%
  • Leg cramps
    7%
  • Diarrhea
    7%
  • Stomach pain
    7%
  • Indigestion
    6%
  • Depression
    6%
  • Difficulty sleeping
    6%
  • Rash
    6%
  • Vaginal bleeding
    6%
  • Vomiting
    5%
  • Swelling
    5%
  • Fever
    4%
  • Tendon disorder
    4%
  • Vertigo
    4%
  • Chest pain
    4%
  • Arthritis
    4%
  • Bladder infection
    4%
  • Breast Pain
    4%
  • Sweating
    3%
  • Uterine disorder
    3%
  • Urinary tract disorder
    3%
  • Flatulence
    3%
  • Stomach and intestinal disorders
    3%
  • Stomach flu
    3%
  • Swelling in arms or legs
    3%
  • Pneumonia
    3%
  • Vaginal discharge
    3%
  • Endometrial disorder
    3%
  • Fainting
    2%
  • Stabbing nerve pain
    2%
  • Pink eye
    2%
  • Migraine
    2%
  • Inflamed vocal cords
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings
  • Increased risk of blood clots and stroke
    • History of blood clots or stroke
    • History of heart disease
    • Long-distance travel
    • Major surgery
    • Prolonged immobilization
    • Smoking
    • Heart failure
    • High blood pressure
  • Premenopausal women
  • Breast cancer
    • History of breast cancer
  • Overdose
    • History of liver disease
    • History of kidney disease
    • Taking estrogen
See more detailed risks and warnings