Compare Boniva vs. Minivelle

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Boniva (ibandronate)

Prescription only

Minivelle (estradiol patch)

Prescription only
Prevents bone loss.

Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.

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2.9/ 5 average rating with 64 reviewsforBoniva
Relieves menopause symptoms.

The Minivelle (estradiol patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

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4.2/ 5 average rating with 17 reviewsforMinivelle
Upsides
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Minivelle (estradiol patch) is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • Causes little or no skin irritation and doesn't leave much adhesive on your skin.
  • Minivelle (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • You need to replace Minivelle (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
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Used for
  • Hot flashes
  • Prevention of bone thinning in postmenopausal women
Dosage forms
  • Pill
  • Injection
  • Patch
Price
Lowest price
$24.49
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Lowest price
$33.14
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Reviews
64 reviews so far
31%
saidit'sworth it
20%
saiditworked well
27%
saidit'sa big hassle

Have you used Boniva (ibandronate)?

Leave a review
17 reviews so far
82%
saidit'sworth it
76%
saiditworked well
18%
saidit'sa big hassle

Have you used Minivelle (estradiol patch)?

Leave a review
Side effects
22possible side effects
  • Abdominal pain
    8%
  • High blood pressure
    6%
  • Indigestion
    6%
  • Joint pain
    6%
  • Nausea
    5%
  • Diarrhea
    5%
  • Back pain
    5%
  • Constipation
    4%
  • Pain in arms or legs
    4%
  • Flu
    4%
  • Cold
    4%
  • Localized joint stiffness and pain
    3%
  • Bronchitis
    3%
  • Headache
    3%
  • Influenza-like illness
    3%
  • Muscle pain
    2%
  • Muscle cramp
    2%
  • Urinary tract infection
    2%
  • Upper respiratory tract infection
    2%
  • Dizziness
    2%
  • Rash
    2%
  • Sleep difficulty
    2%
See more detailed side effects
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Sinus congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
    • History of ulcers, or other stomach or esophageal problems
    • History of difficulty swallowing
    • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Pain in the bones and/or muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Boniva (ibandronate)
  • Leg bone fractures
  • Low calcium in the blood
    • History of low calcium in the blood
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
Learn more about Boniva (ibandronate)
Learn more about Minivelle (estradiol patch)