Compare Byetta vs. Nesina

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Byetta (Exenatide)

Prescription only

Nesina (alogliptin)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers your blood sugar.

Nesina (alogliptin) is a good add-on treatment for diabetes if your blood sugars are still not controlled, but it doesn't work as well as insulin.

Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Less likely to cause weight gain or low blood sugar compared to other anti-diabetic medicines.
  • Pill may be preferred by some patients over injection.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Does not lower your A1c (average blood sugar over time) as much as insulin.
  • Available as an expensive, branded product only.
  • Has more troublesome side-effects than other anti-diabetic pills.
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Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
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Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
The Nesina (alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Loss of medication effectiveness
  • Pancreatitis
  • Kidney problems
    • Severe renal impairment
    • End-stage renal disease
  • Serious stomach problems
    • Severe gastrointestinal disease
    • Gastroparesis
  • Low blood sugar (hypoglycemia)
See more detailed risks and warnings
  • Pancreatitis (inflammation of the pancreas)
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
  • Liver damage
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
    • Taking medicines for diabetes
  • Severe joint pain and swelling
See more detailed risks and warnings