Compare Byetta vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Byetta (Exenatide)

Prescription only

Novolog (insulin aspart)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers blood sugar.

Novolog (insulin aspart) is a fast-acting insulin that provides meal-time blood sugar control. For long-term control, you'll need to take Novolog (insulin aspart) with other medicines to keep your overall blood sugar down.

3.5/ 5 average rating with 177 reviewsforNovolog
Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • When used correctly, this medication will l lower blood sugar every time you use it and prevent the harmful, long-term effects of high sugar levels on your organs and blood vessels.
  • You can easily change the dose of Novolog (insulin aspart) to fit your individual needs.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Can use Novolog (insulin aspart) even if you have liver or kidney problems, unlike many other blood sugar-lowering medicines.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Have to take insulin by injection.
  • Might have to check your blood sugar multiple times a day, usually before each meal.
  • Novolog (insulin aspart) is likely to cause moderate weight gain.
  • Higher risk of low blood sugar episodes compared to other kinds of diabetes medications.
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
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177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

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Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
The Novolog (insulin aspart) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Loss of medication effectiveness
  • Pancreatitis
  • Kidney problems
    • Severe renal impairment
    • End-stage renal disease
  • Serious stomach problems
    • Severe gastrointestinal disease
    • Gastroparesis
  • Low blood sugar (hypoglycemia)
See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Changes in meal pattern or exercise
    • Kidney problems
    • Liver problems
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current imbalance of electrolytes
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings