Compare Byetta vs. Tradjenta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Byetta (Exenatide)

Prescription only

Tradjenta (linagliptin)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers blood sugar.

Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.

Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
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Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
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Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
6possible side effects
  • Back pain
    9%
  • Joint pain
    8%
  • Lung infection
    8%
  • Headache
    6%
  • Cough
    6%
  • Pain in the limbs
    5%
See more detailed side effects
Risks and risk factors
  • Loss of medication effectiveness
  • Pancreatitis
  • Kidney problems
    • Severe renal impairment
    • End-stage renal disease
  • Serious stomach problems
    • Severe gastrointestinal disease
    • Gastroparesis
  • Low blood sugar (hypoglycemia)
See more detailed risks and warnings
  • Inflammation of pancreas (pancreatitis)
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Exercising more than you usually do
    • Insulin
    • Other antidiabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings