Compare Byetta vs. Trulicity

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Byetta (Exenatide)

Prescription only

Trulicity (dulaglutide)

Prescription only
Lowers blood sugar.

Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.

Lowers your blood sugar.

Trulicity (dulaglutide) is a once-weekly injectable medicine that's used to control diabetes, but it can be expensive.

Upsides
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
  • Lowers A1c (average blood sugar over time) up to 1.5%.
  • May help with weight loss and controling appetite.
  • No limitation for people with kidney problems, but close monitoring is recommended.
  • Dosed once a week compared to other injectables that have to be done daily.
  • Medicine is ready to use, without need to mix.
Downsides
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
  • Only available as an injection.
  • Brand name medicine and can be expensive.
  • Many people taking Trulicity (dulaglutide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
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Side effects
3possible side effects
  • Nausea
    8%
  • Vomiting
    4%
  • Upset stomach
    3%
See more detailed side effects
10possible side effects
  • Low blood sugar
    35%
  • Nausea
    21%
  • Diarrhea
    13%
  • Vomiting
    13%
  • Stomach pain
    9%
  • Low appetite
    9%
  • Indigestion
    6%
  • Tiredness
    6%
  • Constipation
    4%
  • Acid reflux
    2%
See more detailed side effects
Risks and risk factors
  • Loss of medication effectiveness
  • Pancreatitis
  • Kidney problems
    • Severe renal impairment
    • End-stage renal disease
  • Serious stomach problems
    • Severe gastrointestinal disease
    • Gastroparesis
  • Low blood sugar (hypoglycemia)
See more detailed risks and warnings
  • Thyroid cancer
    • History of MTC
    • History of MEN 2
  • inflammation of pancreas (pancreatitis)
    • History of pancreatitis
    • History of gallstones
    • alcoholism
    • Elevated triglycerides
  • Severe allergic reactions
  • Kidney damage
    • Kidney problems
    • dehydration
  • Low blood sugar (hypoglycemia)
    • Use of insulin(s)
    • Use of insulin-secreting medicines.
  • Severe stomach problems
    • Stomach or digestive tract disease
    • Gastroparesis
See more detailed risks and warnings