Compare carbidopa / levodopa vs. carbidopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lodosyn (carbidopa)

Prescription only
Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Treats Parkinson's disease when given with levodopa.

Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.

Upsides
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
  • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
  • It is available in a combination pill with levodopa once you find the right dose that works for you.
Downsides
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
  • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Pill
Price
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Reviews
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Side effects
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
The Lodosyn (carbidopa) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Changes in blood pressure and falls
See more detailed risks and warnings