Compare ceftriaxone vs. Omnicef

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Rocephin (ceftriaxone)

Prescription only

Omnicef (cefdinir)

Prescription only
Treats bacterial infections.

Rocephin (ceftriaxone) is good for treating many bacterial infections, but it is only available as an injectable, so it is usually only used in a hospital or doctor's office.

Treats bacterial infections.

Omnicef (cefdinir) is good for treating many common bacterial infections.

Upsides
  • Rocephin (ceftriaxone) is available as a generic.
  • It is good at treating many types of bacterial infections.
  • People usually have few side effects when taking it.
  • Available as a generic, so it shouldn't be too expensive.
  • It is good at killing the most common bacteria.
  • Available in both pill and liquid forms.
Downsides
  • Rocephin (ceftriaxone) is only available as an injectable.
  • If you have to take Rocephin (ceftriaxone) at home, your doctor will have to place a small tube into your skin, and either you or a nurse will inject the medicine.
  • If you're taking Rocephin (ceftriaxone) at home, you have to store it in the fridge, and a nurse might have to see you often to do blood tests.
  • You might not be able to use Rocephin (ceftriaxone) if you've had problems with your large intestine or gallbladder.
  • Antacids and iron prevent Omnicef (cefdinir) from getting absorbed, so you'll need to separate any supplements from Omnicef (cefdinir) by at least 2 hours.
  • If you're taking iron with Omnicef (cefdinir), it can turn your stool red, which is normal but can be alarming.
  • Can cause diarrhea, nausea, vomiting, or headache.
  • The suspension has some sugar in it, which could raise your blood sugar. Talk to your doctor if you have diabetes.
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Used for
Dosage forms
  • Injection
  • Pill
  • Liquid
Price
No pricing information available
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Reviews
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Side effects
4possible side effects
  • High platelets
    5%
  • Diarrhea
    3%
  • Abnormal liver tests
    3%
  • Rash
    2%
See more detailed side effects
4possible side effects
  • Diarrhea
    15%
  • Vaginal yeast infection
    4%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
Risks and risk factors
  • Allergic reaction
    • Allergic to antibiotics (penicillins, cephalosporins)
  • Diarrhea
  • Low blood count
  • Gallbladder problems
    • History of gallbladder disease
    • Severe kidney problems
    • Child
  • Pancreas problems
    • Severe illness
    • Receiving TPN: nutrition given through a vein
See more detailed risks and warnings
  • Diarrhea
    • Taking Omnicef (cefdinir) for a long time
  • Allergic reaction
    • History of penicillin allergy
  • Drug interactions
    • Taking antacids or iron supplements
See more detailed risks and warnings