Compare Celebrex vs. Allopurinol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT

Celebrex (celecoxib)

Prescription only

Zyloprim (allopurinol)

Prescription only
Relieves pain and inflammation.

Celebrex (celecoxib) works well for treating pain, but is not a good option if you have heart problems.

3.4/ 5 average rating with 550 reviewsforCelebrex
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

3.7/ 5 average rating with 21 reviewsforAllopurinol
Upsides
  • Celebrex (celecoxib) effectively relieves pain and inflammation for many types of pain conditions including osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, and menstrual cramps.
  • Celebrex (celecoxib) causes less stomach problems compared to other NSAIDs like ibuprofen or naproxen.
  • Celebrex (celecoxib) is available as a cheaper, generic form.
  • Celebrex (celecoxib) has the lowest risk of heart attack compared to other NSAIDs.
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
Downsides
  • The longer you take Celebrex (celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding.
  • Celebrex (celecoxib) can affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Celebrex (celecoxib) shouldn't be used if you have an allergy to sulfa medications.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Pill
  • Injection
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
550 reviews so far
57%
saidit'sworth it
38%
saiditworked well
14%
saidit'sa big hassle

Have you used Celebrex (celecoxib)?

Leave a review
21 reviews so far
71%
saidit'sworth it
52%
saiditworked well
5%
saidit'sa big hassle

Have you used Zyloprim (allopurinol)?

Leave a review
Side effects
16possible side effects
  • Headache
    16%
  • Indigestion
    9%
  • Upper respiratory infection
    8%
  • Diarrhea
    6%
  • Sinus infection
    5%
  • Stomach pain
    4%
  • Nausea
    4%
  • Back pain
    3%
  • Injury
    3%
  • Gas
    2%
  • Swelling in the limbs
    2%
  • Dizziness
    2%
  • Difficulty sleeping
    2%
  • Sore throat
    2%
  • Stuffy nose
    2%
  • Rash
    2%
See more detailed side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • Long-term use
    • History of heart disease
    • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Stomach bleeding
    • Age 65 or older
    • History of GI bleed or peptic ulcer disease
    • Longer duration of treatment
    • Use of oral corticosteroids, aspirin, anticoagulants, selective serotonin reuptake inhibitors (SSRIs)
    • Smoking
    • Alcohol use
  • Increased blood pressure
    • History of high blood pressure
  • Heart failure risk
    • Heart failure
  • Allergic reaction
    • History of sulfa allergy
  • Lowered kidney function
    • History of kidney problems
    • Dehydration
    • Heart failure
    • Liver problems
    • Taking diuretic medications
    • ACE inhibitors
    • Angiotensin II receptor blockers
    • Age 65 or older
See more detailed risks and warnings
  • More gout attacks
  • Kidney stones
    • History of kidney stones
  • Skin rash
  • Liver disease
  • Sleepiness or dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
See more detailed risks and warnings