Compare Celebrex vs. Tylenol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves pain and inflammation.

Celebrex (celecoxib) works well for treating pain, but is not a good option if you have heart problems.

3.4/ 5 average rating with 550 reviewsforCelebrex
Relieves pain and fever.

Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.

3.7/ 5 average rating with 1002 reviewsforTylenol
Upsides
  • Celebrex (celecoxib) effectively relieves pain and inflammation for many types of pain conditions including osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, and menstrual cramps.
  • Celebrex (celecoxib) causes less stomach problems compared to other NSAIDs like ibuprofen or naproxen.
  • Celebrex (celecoxib) is available as a cheaper, generic form.
  • Celebrex (celecoxib) has the lowest risk of heart attack compared to other NSAIDs.
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
Downsides
  • The longer you take Celebrex (celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding.
  • Celebrex (celecoxib) can affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Celebrex (celecoxib) shouldn't be used if you have an allergy to sulfa medications.
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
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Used for
Dosage forms
  • Pill
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
Price
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Reviews
550 reviews so far
57%
saidit'sworth it
38%
saiditworked well
14%
saidit'sa big hassle

Have you used Celebrex (celecoxib)?

Leave a review
1002 reviews so far
77%
saidit'sworth it
37%
saiditworked well
3%
saidit'sa big hassle

Have you used Tylenol Regular Strength (acetaminophen)?

Leave a review
Side effects
16possible side effects
  • Headache
    16%
  • Indigestion
    9%
  • Upper respiratory infection
    8%
  • Diarrhea
    6%
  • Sinus infection
    5%
  • Stomach pain
    4%
  • Nausea
    4%
  • Back pain
    3%
  • Injury
    3%
  • Gas
    2%
  • Swelling in the limbs
    2%
  • Dizziness
    2%
  • Difficulty sleeping
    2%
  • Sore throat
    2%
  • Stuffy nose
    2%
  • Rash
    2%
See more detailed side effects
The Tylenol Regular Strength (acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • Long-term use
    • History of heart disease
    • History of heart bypass surgery (coronary artery bypass graft/CABG)
  • Stomach bleeding
    • Age 65 or older
    • History of GI bleed or peptic ulcer disease
    • Longer duration of treatment
    • Use of oral corticosteroids, aspirin, anticoagulants, selective serotonin reuptake inhibitors (SSRIs)
    • Smoking
    • Alcohol use
  • Increased blood pressure
    • History of high blood pressure
  • Heart failure risk
    • Heart failure
  • Allergic reaction
    • History of sulfa allergy
  • Lowered kidney function
    • History of kidney problems
    • Dehydration
    • Heart failure
    • Liver problems
    • Taking diuretic medications
    • ACE inhibitors
    • Angiotensin II receptor blockers
    • Age 65 or older
See more detailed risks and warnings
  • Accidental overdose and death
    • Medication administering errors
    • Injection formulation
    • Exceeding the recommended maximum daily limits
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
See more detailed risks and warnings