Compare Celexa vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Celexa (citalopram)

Prescription only

Lyrica (pregabalin)

Prescription only
Improves mood.

Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems.

3.7/ 5 average rating with 520 reviewsforCelexa
Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

3.3/ 5 average rating with 66 reviewsforLyrica
Upsides
  • Effectively relieves depression symptoms.
  • This medicine is not as drowsy as other antidepressants.
  • Available as a generic, which is cheaper.
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
Downsides
  • Can cause sexual side effects like decreased sex drive, difficulties with orgasm or ejaculation, and minor weight gain (1 to 5 pounds).
  • Celexa (citalopram) may not be a good option if you have heart or liver problems.
  • Like most antidepressants, Celexa (citalopram) can increase risk of suicidal thoughts and behavior in people younger than 24 years.
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
520 reviews so far
61%
saidit'sworth it
51%
saiditworked well
16%
saidit'sa big hassle

Have you used Celexa (citalopram)?

Leave a review
66 reviews so far
47%
saidit'sworth it
42%
saiditworked well
32%
saidit'sa big hassle

Have you used Lyrica (pregabalin)?

Leave a review
Side effects
25possible side effects
  • Nausea
    21%
  • Dry mouth
    20%
  • Drowsiness
    18%
  • Difficulty sleeping
    15%
  • Increased sweating
    11%
  • Tremor
    8%
  • Diarrhea
    8%
  • Abnormal ejaculation
    6%
  • Indigestion
    5%
  • Fatigue
    5%
  • Upper airway infection
    5%
  • Stuffy nose
    5%
  • Vomiting
    4%
  • Anxiety
    4%
  • Anorexia
    4%
  • Abdominal pain
    3%
  • Agitation
    3%
  • Menstrual cramps
    3%
  • Sinus infection
    3%
  • Erection difficulties
    3%
  • Fever
    2%
  • Joint pain
    2%
  • Muscle pain
    2%
  • Decreased sex drive
    2%
  • Yawning
    2%
See more detailed side effects
28possible side effects
  • Dizziness
    23%
  • Drowsiness
    13%
  • Headache
    11%
  • Blurry vision
    8%
  • Weight gain
    8%
  • Dry mouth
    7%
  • Fatigue
    5%
  • Swelling of the hands and feet
    5%
  • Constipation
    4%
  • Sinus infection
    4%
  • Increased appetite
    4%
  • Joint pain
    4%
  • Loss of focus
    4%
  • Feeling off balance
    2%
  • Vomiting
    2%
  • Abdominal distension
    2%
  • Chest pain
    2%
  • Fluid retention
    2%
  • Muscle spasms
    2%
  • Back pain
    2%
  • Balance disorder
    2%
  • Abnormal coordination
    2%
  • Partial loss of sensitivity to touch
    2%
  • Lethargy
    2%
  • Intense feeling of happiness
    2%
  • Anxiety
    2%
  • Depression
    2%
  • Sore throat
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Withdrawal
    • Stopping Celexa (citalopram) abruptly
  • Lower maximum dose in some people
    • Higher dose
    • History of heart problems
    • History of liver problems
    • 60 years or older
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Sexual side effects
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Starting Lyrica (pregabalin) or changing doses
  • Driving impairment
    • Taking Lyrica (pregabalin) with alcohol
    • Taking other medicines that make you drowsy
  • Giant hives (angioedema)
    • History of unusual swelling (angioedema)
    • Taking other medications (ie. lisinopril) that can cause angioedema
  • Heart problems
    • History of cardiovascular disease
  • Swelling of the hands and feet
    • Taking with certain diabetes medications
  • Withdrawal symptoms
    • Stopping Lyrica (pregabalin) suddenly
See more detailed risks and warnings