Compare chlorpromazine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Mellaril (thioridazine)

Prescription only
Stabilizes your mood.

Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.

Treats schizophrenia.

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.

Upsides
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
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Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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Reviews
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Side effects
The Thorazine (chlorpromazine) FDA package insert doesn’t have numbers about how common side effects are.
The Mellaril (thioridazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Breathing problems
    • Asthma
    • COPD
    • Acute respiratory infections
  • Heat stroke and dehydration
    • Benign prostatic hypertrophy (BPH)
    • Urinary retention
    • Decreased movement in the intestines
See more detailed risks and warnings
  • Problems with the heartbeat
    • History of heartbeat problems
    • Taking medicines for depression
    • Taking beta blockers
  • Increased risk of death in elderly people with dementia
    • People older than 65 years with dementia and psychosis
  • Difficulty controlling movements
    • Long-term use of Mellaril (thioridazine)
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Sleepiness and risk of falls
    • Drinking alcohol or taking narcotics
  • Decreased white blood cells
    • History of low white blood cells
See more detailed risks and warnings