Compare chlorpromazine vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Zyprexa (olanzapine)

Prescription only
Stabilizes your mood.

Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.

Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

3.7/ 5 average rating with 68 reviewsforZyprexa
  • Acts fast to slow you down during a psychotic episode.
  • Can also be used for nausea or migraines.
  • Safe for use in children as young as 6 months.
  • Comes in a sugar-coated pill for easy administration.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Has more side effects than other medicines like it.
  • Can affect how your other medicines work.
  • Makes you more sensitive to the sun.
  • Can make you dizzy or lightheaded, especially when injected.
  • Cannot be stopped right away.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
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Side effects
The Thorazine (chlorpromazine) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Drowsiness
  • Weight gain
  • Increased appetite
  • Headache
  • Fatigue
  • Dizziness
  • Dry Mouth
  • Abdominal pain
  • Pain in extremity
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Breathing problems
    • Asthma
    • COPD
    • Acute respiratory infections
  • Heat stroke and dehydration
    • Benign prostatic hypertrophy (BPH)
    • Urinary retention
    • Decreased movement in the intestines
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar, high cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings