Compare chlorthalidone vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood pressure. Removes extra water from your body.

Thalitone (chlorthalidone) is a well-tolerated water pill that's increasingly used to treat high blood pressure.

Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A good blood pressure treatment for people who haven't responded well to other thiazide diuretics. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
Downsides
  • Makes you urinate more often.
  • Doesn't work well in people with severe kidney problems.
  • Since Thalitone (chlorthalidone) works longer in the body than other thiazide diuretics, it has a higher chance of causing electrolyte changes.
  • Thalitone (chlorthalidone) can lead to more gouty attacks in people with gout.
  • Don't use this if you have a sulfa allergy.
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
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Reviews
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Side effects
The Thalitone (chlorthalidone) FDA package insert doesn’t have numbers about how common side effects are.
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Electrolyte disturbances
  • Higher risk for gout attacks
    • History of gout
  • Increased blood sugars
    • History of diabetes
  • Reduced kidney performance
    • History of kidney disease
    • History of acute kidney failure
    • History of azotemia
  • Caution in liver disease
    • History of liver problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Tumor development
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Taking other medicines that increase potassium
    • Use of salt substitutes
  • Breast pain or swelling
See more detailed risks and warnings