Compare chlorzoxazone vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves muscle pain caused by spasms.

While Parafon Forte DSC (chlorzoxazone) can be used to treat muscle pain, it can have bad side effects.

Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

Upsides
  • Parafon Forte DSC (chlorzoxazone) works just as well as other medicines used for muscle pain caused by spasms.
  • Parafon Forte DSC (chlorzoxazone) is available in generic.
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
Downsides
  • For muscle pain such as back or neck pain, anti-inflammatory medicines like ibuprofen or naproxen are preferred over Parafon Forte DSC (chlorzoxazone).
  • Parafon Forte DSC (chlorzoxazone) is not recommended if you're over 65 because it can make you more sleepy and more likely to break your bones.
  • Parafon Forte DSC (chlorzoxazone) works best with physical therapy and rest.
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
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Used for
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
The Parafon Forte DSC (chlorzoxazone) FDA package insert doesn’t have numbers about how common side effects are.
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver damage
    • Taking acetaminophen (Tylenol) with Parafon Forte DSC (chlorzoxazone)
  • Central nervous system depression
    • Alcohol
    • Taking narcotics, tranquilizers or antihistamines
  • Skin rashes
    • Allergies to muscle relaxants
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings