Compare chlorzoxazone vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves muscle pain caused by spasms.

While Parafon Forte DSC (chlorzoxazone) can be used to treat muscle pain, it can have bad side effects.

Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

4.3/ 5 average rating with 26 reviewsforZanaflex
Upsides
  • Parafon Forte DSC (chlorzoxazone) works just as well as other medicines used for muscle pain caused by spasms.
  • Parafon Forte DSC (chlorzoxazone) is available in generic.
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides
  • For muscle pain such as back or neck pain, anti-inflammatory medicines like ibuprofen or naproxen are preferred over Parafon Forte DSC (chlorzoxazone).
  • Parafon Forte DSC (chlorzoxazone) is not recommended if you're over 65 because it can make you more sleepy and more likely to break your bones.
  • Parafon Forte DSC (chlorzoxazone) works best with physical therapy and rest.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
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Reviews
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26 reviews so far
81%
saidit'sworth it
73%
saiditworked well
19%
saidit'sa big hassle

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Side effects
The Parafon Forte DSC (chlorzoxazone) FDA package insert doesn’t have numbers about how common side effects are.
17possible side effects
  • Dry mouth
    49%
  • Sleepiness
    48%
  • Weakness
    41%
  • Dizziness
    16%
  • Urinary tract infection
    10%
  • General infection
    6%
  • Liver test abnormality
    6%
  • Constipation
    4%
  • Vomiting
    3%
  • Speech disorder
    3%
  • Blurred vision
    3%
  • Urinary frequency
    3%
  • Flu syndrome
    3%
  • Involuntary muscle movement
    3%
  • Nervousness
    3%
  • Sore throat
    3%
  • Hay fever
    3%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • Taking acetaminophen (Tylenol) with Parafon Forte DSC (chlorzoxazone)
  • Central nervous system depression
    • Alcohol
    • Taking narcotics, tranquilizers or antihistamines
  • Skin rashes
    • Allergies to muscle relaxants
See more detailed risks and warnings
  • Liver damage
    • Taking maximum doses of Zanaflex (tizanidine)
  • Dizziness and low blood pressure
    • Age 65 years or older
    • Currently on blood pressure control medications
  • Sleepiness and driving impairment
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
  • Withdrawal side effects
    • Stopping Zanaflex (tizanidine) suddenly
See more detailed risks and warnings