Compare ciclopirox vs. Diflucan

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Loprox (ciclopirox)

Prescription only

Diflucan (fluconazole)

Prescription only
Treats fungal infections on nails, scalp, and skin.

Loprox (ciclopirox) is a cheap, effective treatment for fungal infections that have not penetrated past the skin, but requires daily application for weeks to months to see an improvement.

Treats yeast and other fungal infections.

Diflucan (fluconazole) is a cheap and effective treatment for fungal infections.

3.9/ 5 average rating with 30 reviewsforDiflucan
  • Has few side effects compared to oral anti-fungal medications.
  • Easy to use and can be applied directly on the infected areas of the skin.
  • Safe to use for even people who have liver or kidney disease.
  • Available in cheap, generic version.
  • Available in a cheap generic version.
  • Single dose treatment for vaginal infections.
  • Available as a pill, liquid, or injection.
  • You might need to use Loprox (ciclopirox) for many months to treat your condition.
  • In cases where Loprox (ciclopirox) is used on nails, you might need to remove the medication with alcohol every 7 days.
  • Not the best treatment option for severe and complicated fungal infections.
  • Excessive use of alcohol while on this medicine can harm your liver.
  • Can interfere with how other medicines work, especially birth control pills.
Used for
Dosage forms
  • Cream
  • Gel
  • Liquid
  • Shampoo
  • Lotion
  • Pill
  • Liquid
  • Injection
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Side effects
The Loprox (ciclopirox) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhea
See more detailed side effects
Risks and risk factors
  • For external use only
  • Allergic reactions
See more detailed risks and warnings
  • Liver disease
  • Serious immediate allergic reaction
  • Skin rash
  • Use in pregnancy
See more detailed risks and warnings