Compare Ciloxan vs. Zylet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats eye infections.

Ciloxan (ciprofloxacin) effectively treats pink eye and corneal ulcers caused by a variety of bacteria, but might not be good for more serious infections.

Treats certain eye inflammation and infections.

Zylet (loteprednol and tobramycin) is a good choice for certain eye infections and conditions, but isn't for everyone and you can't use it for a long time.

  • Ciloxan (ciprofloxacin) has a high success rate in treating people with pink eye and corneal ulcers.
  • Has fewer side effects compared to alternative oral medications since Ciloxan (ciprofloxacin) is applied directly to the eyes.
  • Ciloxan (ciprofloxacin) eyedrops are available in an inexpensive, generic form.
  • The ointment helps to lubricate and soothe the eye.
  • Applied less frequently than other eye drops.
  • Zylet (loteprednol and tobramycin) is very effective at reducing inflammation and treating infection in certain eye conditions.
  • Since Zylet (loteprednol and tobramycin) is applied directly into the eye, you won't experience any severe body side effects.
  • Ciloxan (ciprofloxacin) drops require frequent applications, especially during the first few days of treatment.
  • Ciloxan (ciprofloxacin) ointment is expensive because a generic is not available.
  • The ointment can cause blurry vision for a few minutes after applying.
  • Application of Ciloxan (ciprofloxacin) can temporarily irritate the eyes.
  • Zylet (loteprednol and tobramycin) is expensive.
  • Taking Zylet (loteprednol and tobramycin) can be burdensome, as you have to use it multiple times a day.
  • There's a limit to how much Zylet (loteprednol and tobramycin) can be used.
Used for
  • Steroid responsive eye inflammation conditions
  • Superficial eye infections
  • Blepharitis
Dosage forms
  • Eye drops
  • Eye ointment
  • Eye drops
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Side effects
The Ciloxan (ciprofloxacin) FDA package insert doesn’t have numbers about how common side effects are.
12possible side effects
  • Headache
  • Increased eye pressures
  • Eye burning
  • Eye stinging
  • Vision problems
  • Eye discharge
  • Eye itching
  • Tearing problems
  • Light sensitivity
  • Eye deposits
  • Eyelid problems
  • Other non-specific eye disorders
See more detailed side effects
Risks and risk factors
  • Allergy to ingredients
    • Allergies to quinolone antibiotics such as Levaquin and Cipro
  • Risk for contamination
  • Not to be used with contact lenses
  • Risk of infection
    • Prolonged use
See more detailed risks and warnings
  • Increased eye pressure
    • Taking Zylet (loteprednol and tobramycin) with other steroids
  • Cataracts
  • Delayed healing
    • Recent cataract surgery
    • Cornea problems
  • Second infections
    • Acute purulent eye infections
  • Allergic reaction
See more detailed risks and warnings