Compare Cimzia vs. Orencia
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Calms the immune system and prevents joint damage.
Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.
Calms down the immune system and prevents joint damage.
Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.
- People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
- Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
- You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
- After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
- Cimzia (certolizumab) has been on the market for almost 10 years.
- In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
- Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
- Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
- You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
- Available in a prefilled autoinjector for convenient use.
- Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
- Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
- In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
- Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
- There's no generic available and it can be expensive.
- Orencia (abatacept) can be costly.
- The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
- The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
- If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
- Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
- Rheumatoid Arthritis
- Polyarticular Juvenile Idiopathic Arthritis
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4possible side effects
- Upper airway infections20%
- Urinary tract infections7%
- Joint pain6%
10possible side effects
- Common cold12%
- Back pain7%
- High blood pressure7%
- Urinary tract infection6%
- Pain in arms or legs3%
Risks and risk factors
- Serious infections
- Taking other immunosuppressant medications such as methotrexate or steroids
- Age 65 or older
- Active, chronic, or recurrent infection
- Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
- History of malignancy
- Adolescent age
- Heart problems
- History of heart failure
- Serious allergic reactions
- Lower blood cell counts
- Nervous system effects
- Multiple sclerosis
- Guillain-Barre syndrome
- High risk of infections with TNF inhibitors
- Using TNF inhibitors
- Severe allergic reactions
- Lower effectiveness of vaccines
- Immunosuppression and Infections
- Taking immunosuppressive medications
- History of repeat infections
- Adults with rheumatoid arthritis taking TNF inhibitors
- More COPD side effects