Compare Cimzia vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cimzia (certolizumab)

Prescription only

Simponi (golimumab)

Prescription only
Calms the immune system and prevents joint damage.

Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.

Calms down the immune system.

Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.

Upsides
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
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Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
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Side effects
4possible side effects
  • Infections
    38%
  • Upper airway infections
    20%
  • Urinary tract infections
    7%
  • Joint pain
    6%
See more detailed side effects
11possible side effects
  • Common cold
    16%
  • Injection site reaction
    6%
  • Viral infections (such as influenza and herpes)
    5%
  • Increased liver function test (ALT)
    4%
  • Increased liver function test (AST)
    3%
  • High blood pressure
    3%
  • Bronchitis
    2%
  • Superficial fungal infections
    2%
  • Sinusitis
    2%
  • Dizziness
    2%
  • Tingling sensation
    2%
See more detailed side effects
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant medications such as methotrexate or steroids
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
  • Cancers
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
    • History of malignancy
    • Adolescent age
  • Heart problems
    • History of heart failure
  • Serious allergic reactions
  • Lower blood cell counts
  • Nervous system effects
    • Multiple sclerosis
    • Guillain-Barre syndrome
See more detailed risks and warnings
  • High risk of infections with TNF inhibitors
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Active, chronic, or recurrent infection
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
    • People with rheumatoid arthritis
    • Adolescent age
  • Nervous system effects
    • History of neurologic condition
  • History of heart failure
    • History of heart failure
  • Lower number of blood cells
See more detailed risks and warnings