Compare Cipro vs. doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cipro (ciprofloxacin)

Prescription only

Vibramycin (doxycycline)

Prescription only
Treats bacterial infections.

Cipro (ciprofloxacin) is a good, cheap antibiotic that treats many types of bacterial infections, but it interacts with some food and drugs.

3.8/ 5 average rating with 755 reviewsforCipro
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

3.2/ 5 average rating with 112 reviewsfordoxycycline
Upsides
  • Cipro (ciprofloxacin) is available in generic.
  • Cipro (ciprofloxacin) comes in different forms, including intravenous (IV) injection.
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
Downsides
  • Cipro (ciprofloxacin) should be used with caution if you have kidney problems.
  • If you drink caffeine while on Cipro (ciprofloxacin), you may notice increased effects of the caffeine.
  • Some bacteria have developed resistance to Cipro (ciprofloxacin).
  • Cipro (ciprofloxacin) can interact with many other medications. Tell your doctor and pharmacist what medications, over-the-counter products, and supplements you are taking before starting Cipro (ciprofloxacin).
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Extended release pill
  • Pill
  • Delayed release pill
  • Liquid
Price
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Reviews
755 reviews so far
63%
saidit'sworth it
53%
saiditworked well
17%
saidit'sa big hassle

Have you used Cipro (ciprofloxacin)?

Leave a review
112 reviews so far
49%
saidit'sworth it
36%
saiditworked well
24%
saidit'sa big hassle

Have you used Vibramycin (doxycycline)?

Leave a review
Side effects
2possible side effects
  • Nausea
    3%
  • Diarrhea
    2%
See more detailed side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tendon rupture
    • People over age 60
    • Taking steroid medicine
    • Those with kidney, heart, or lung transplants
  • Myasthenia gravis
    • Myasthenia gravis
  • Diarrhea
  • Nerve damage
  • Central nervous system effects
    • Central nervous system disorders
    • Seizures
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
See more detailed risks and warnings
  • Color changes in teeth of young children and unborn babies
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
  • Severe diarrhea
    • Using Vibramycin (doxycycline) for a long period of time
  • Sunburn or rash
    • Being in the sun for a long period of time
    • Using tanning salons
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings