Compare Cleocin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats acne.

Cleocin (clindamycin) is proven to be effective at treating acne when combined with another acne medicine and is available in a variety of formulations.

3.5/ 5 average rating with 115 reviewsforCleocin
Kills bacteria.

Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.

3.6/ 5 average rating with 473 reviewsforBactrim
Upsides
  • Available in generic.
  • Comes in different formulations (gel, solution, lotion, foam) to fit your preferences.
  • Works well for the kind of acne that causes large, red, and swollen pimples.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
Downsides
  • Foam formulation can cause headaches.
  • You will likely have to use another acne medicine along with Cleocin (clindamycin) since it is not as effective by itself.
  • Is only preferred for mild to moderate acne. If you have severe acne your doctor will most likely prescribe an oral medication.
  • If you only have comedonal acne (small skin-colored bumps on the skin) without any red, swollen pimples, your doctor may give you an alternative medicine.
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
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Used for
Dosage forms
  • Gel
  • Foam
  • Solution
  • Lotion
  • Pill
  • Liquid
Price
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Reviews
115 reviews so far
57%
saidit'sworth it
43%
saiditworked well
19%
saidit'sa big hassle

Have you used Cleocin (clindamycin)?

Leave a review
473 reviews so far
59%
saidit'sworth it
49%
saiditworked well
22%
saidit'sa big hassle

Have you used Bactrim (sulfamethoxazole / trimethoprim)?

Leave a review
Side effects
9possible side effects
  • Dryness
    23%
  • Oiliness/Oily skin
    18%
  • Redness
    16%
  • Burning
    11%
  • Burning/Itching
    11%
  • Peeling
    11%
  • Itching
    11%
  • Burning where applied
    6%
  • Headache
    3%
See more detailed side effects
The Bactrim (sulfamethoxazole / trimethoprim) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Severe diarrhea and stomach cramps
    • Using Cleocin (clindamycin) for a long time
See more detailed risks and warnings
  • Diarrhea
  • Sunburn
  • Rash
  • Harm to fetus
  • Lower kidney function
    • Elderly
    • Taking other medicines that lower kidney function
See more detailed risks and warnings