Compare Cleocin vs. daptomycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cleocin (clindamycin)

Prescription only

Cubicin (daptomycin)

Prescription only
Treats acne.

Cleocin (clindamycin) is proven to be effective at treating acne when combined with another acne medicine and is available in a variety of formulations.

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3.5/ 5 average rating with 115 reviewsforCleocin
Treats bacterial infections.

Cubicin (daptomycin) is an antibiotic that's usually only given in the hospital for serious infections. It can be given at home, but you will have to be taught how to inject it correctly.

Upsides
  • Available in generic.
  • Comes in different formulations (gel, solution, lotion, foam) to fit your preferences.
  • Works well for the kind of acne that causes large, red, and swollen pimples.
  • Cubicin (daptomycin) is good at treating severe and complicated bacterial infections.
  • It is able to kill bacteria that have resistance to other antibiotics.
  • Most people who take Cubicin (daptomycin) have few side effects.
  • You usually only need to take it once a day.
Downsides
  • Foam formulation can cause headaches.
  • You will likely have to use another acne medicine along with Cleocin (clindamycin) since it is not as effective by itself.
  • Is only preferred for mild to moderate acne. If you have severe acne your doctor will most likely prescribe an oral medication.
  • If you only have comedonal acne (small skin-colored bumps on the skin) without any red, swollen pimples, your doctor may give you an alternative medicine.
  • Cubicin (daptomycin) is usually only given for extremely serious infections that haven't responded to other antibiotics.
  • Cubicin (daptomycin) can cause muscle aches and weakness, which can lead to kidney problems.
  • You might need to have more blood tests done while taking Cubicin (daptomycin).
  • Like most antibiotics, it is common to have diarrhea when taking this medicine.
  • While Cubicin (daptomycin) is generic, it is usually very expensive.
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Used for
Dosage forms
  • Gel
  • Foam
  • Solution
  • Lotion
  • Injection
Price
Lowest price
$100.31
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Reviews
115 reviews so far
57%
saidit'sworth it
43%
saiditworked well
19%
saidit'sa big hassle

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Side effects
9possible side effects
  • Dryness
    23%
  • Oiliness/Oily skin
    18%
  • Redness
    16%
  • Burning
    11%
  • Burning/Itching
    11%
  • Peeling
    11%
  • Itching
    11%
  • Burning where applied
    6%
  • Headache
    3%
See more detailed side effects
9possible side effects
  • Diarrhea
    5%
  • Headache
    5%
  • Rash
    4%
  • Abnormal liver tests
    3%
  • Muscle damage
    3%
  • Dizziness
    2%
  • Urinary tract infection
    2%
  • Low blood pressure
    2%
  • Shortness of breath
    2%
See more detailed side effects
Risks and risk factors
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Severe diarrhea and stomach cramps
    • Using Cleocin (clindamycin) for a long time
See more detailed risks and warnings
  • Allergic reaction
    • Allergy to antibiotics
  • Muscle pain & kidney damage
    • History of kidney problems
    • Taking statins to lower cholesterol
  • Pneumonia
    • Taking Cubicin (daptomycin) for at least 2 to 4 weeks
  • Nerve damage
  • Diarrhea
See more detailed risks and warnings
Learn more about Cleocin (clindamycin)
Learn more about Cubicin (daptomycin)