Compare Cleocin vs. Zyvox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Cleocin (clindamycin)

Prescription only

Zyvox (linezolid)

Prescription only
Treats acne.

Cleocin (clindamycin) is proven to be effective at treating acne when combined with another acne medicine and is available in a variety of formulations.

3.5/ 5 average rating with 115 reviewsforCleocin
Treats bacterial infections.

Zyvox (linezolid) is good first-choice treatment for serious infections caused by gram positive bacteria.

Upsides
  • Available in generic.
  • Comes in different formulations (gel, solution, lotion, foam) to fit your preferences.
  • Works well for the kind of acne that causes large, red, and swollen pimples.
  • Zyvox (linezolid) is effective at treating serious infections caused by certain types of bacteria.
  • Zyvox (linezolid) can be taken orally in liquid form or injected if you have trouble swallowing pills.
Downsides
  • Foam formulation can cause headaches.
  • You will likely have to use another acne medicine along with Cleocin (clindamycin) since it is not as effective by itself.
  • Is only preferred for mild to moderate acne. If you have severe acne your doctor will most likely prescribe an oral medication.
  • If you only have comedonal acne (small skin-colored bumps on the skin) without any red, swollen pimples, your doctor may give you an alternative medicine.
  • Zyvox (linezolid) can cause dangerously high blood pressures when combined with certain depression medications or excessive amounts of cheese or alcohol.
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Used for
Dosage forms
  • Gel
  • Foam
  • Solution
  • Lotion
  • Pill
  • Liquid
  • Injection
Price
Lowest price
$4977.33
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Reviews
115 reviews so far
57%
saidit'sworth it
43%
saiditworked well
19%
saidit'sa big hassle

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Side effects
9possible side effects
  • Dryness
    23%
  • Oiliness/Oily skin
    18%
  • Redness
    16%
  • Burning
    11%
  • Burning/Itching
    11%
  • Peeling
    11%
  • Itching
    11%
  • Burning where applied
    6%
  • Headache
    3%
See more detailed side effects
9possible side effects
  • Diarrhea
    8%
  • Nausea
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Dizziness
    2%
  • Rash
    2%
  • Anemia
    2%
  • Fungal infection of the mouth
    2%
  • Abnormal liver function
    2%
See more detailed side effects
Risks and risk factors
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Severe diarrhea and stomach cramps
    • Using Cleocin (clindamycin) for a long time
See more detailed risks and warnings
  • Blood and bone marrow problems
    • Taking Zyvox (linezolid) for longer than 2 weeks
    • Existing bone marrow disease
    • Use of other medicines that affect the bone marrow suppression
    • Chronic infection
    • Use of other antibiotic therapies
  • Nerve and eye damage
  • Serotonin syndrome
    • Taking drugs for depression, migraines, or pain
  • Infectious diarrhea
    • Taking Zyvox (linezolid) for a long time
  • Acid buildup in the blood (lactic acidosis)
  • Low blood sugar
    • Diabetes
    • Using insulin or other diabetic medications
See more detailed risks and warnings