Compare Climara Pro vs. estradiol / norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves hot flashes and lowers your risk of osteoporosis.

The Climara Pro (estradiol / levonorgestrel patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combination medications but prefer to use a patch once a week instead of pills every day.

Relieves menopause symptoms and lowers your risk of osteoporosis.

Activella (estradiol / norethindrone) helps relieve menopausal symptoms and prevent bone loss. There can be many side effects, so it's important to talk to your doctor about the benefits and potential hassles of this drug before using it.

Upsides
  • Once-a-week patch. Good for people who don't want to take daily pills.
  • Replaces estrogen in your body and relieves multiple symptoms from low estrogen, such as hot flashes and vaginal dryness.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The progestin in the patch protects against the risk of cancer in the uterus.
  • The Climara Pro (estradiol / levonorgestrel patch) patch has a lower risk of causing blood clots and stroke compared to other forms containing the same medicines.
  • Replaces estrogen in your entire body and relieves multiple symptoms of menopause.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Improves mood, energy, and mental alertness for some people.
  • Generic available, so cost is usually lower.
Downsides
  • More potential side effects than medications with one ingredient since Climara Pro (estradiol / levonorgestrel patch) exposes your whole body to two hormones.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can fall off, especially if you like to regularly swim, take baths, or use saunas.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since Activella (estradiol / norethindrone) exposes your whole body to two hormones.
  • Raises your risk of developing a stroke and blood clots.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Should only use if you still have a uterus.
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Used for
  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis
  • Hot flashes
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Patch
  • Pill
Price
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Reviews
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Side effects
22possible side effects
  • Skin irritation
    41%
  • Vaginal bleeding
    37%
  • Breast pain
    19%
  • Lung infection
    13%
  • Back pain
    6%
  • Depression
    6%
  • Flu like symptoms
    5%
  • Pain
    5%
  • Headache
    5%
  • Stomach pain
    4%
  • Gas
    4%
  • Swelling of arms and legs
    4%
  • Joint pain
    4%
  • Airway inflammation
    4%
  • Sinus infection
    4%
  • Accidental injury
    3%
  • Infection
    3%
  • High blood pressure
    3%
  • Weight gain
    3%
  • Bladder infection
    3%
  • Rash
    2%
  • Vaginal inflammation
    2%
See more detailed side effects
10possible side effects
  • Breast pain
    21%
  • Headache
    17%
  • Nausea
    10%
  • Upper airway infection
    10%
  • Post-menopausal bleeding
    10%
  • Sinus infection
    7%
  • Ovarian cyst
    7%
  • Back pain
    3%
  • Difficulty sleeping
    3%
  • Accidental injury
    3%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than 1 year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • High blood pressure
    • Smoking
    • Obesity
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • History of high triglycerides
See more detailed risks and warnings