Compare Clindesse vs. Clotrimazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats bacterial vaginal infections with a single dose.

Clindesse (clindamycin) treats vaginal infections and is very easy to use.

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Upsides
  • Very easy to use and works within a few days.
  • Generic available, so cost is lower.
  • Doesn't have many side effects.
  • You can stand up and walk around right after you use it, so you can use it at any time of day.
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Downsides
  • Can cause yeast infections in some women.
  • After using Clindesse (clindamycin), must avoid sex and using tampons for 7 days.
  • Can very rarely cause severe diarrhea.
  • Cannot be used if you have bowel diseases like Crohn's disease or ulcerative colitis.
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Used for
  • Candidal vulvovaginitis Candidiasis
  • Topical Oropharyngeal candidiasis Oropharyngeal candidiasis; Prophylaxis Pityriasis versicolor Tinea corporis Tinea cruris Tinea pedis
  • Candidal vulvovaginitis
  • Recurrent; Prophylaxis
Dosage forms
  • Cream
  • Cream, gel, or ointment
  • Topical
  • Spray
  • Topical
  • Lozenge
Price
Lowest price
$12.25
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Lowest price
$7.52
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Reviews
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Side effects
5possible side effects
  • Yeast infection
    14%
  • Headache
    7%
  • Back pain
    5%
  • Constipation
    2%
  • Bladder infection
    2%
See more detailed side effects
The Lotrimin (Clotrimazole) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Allergy alert
    • Known allergy to clindamycin
    • Known allergy to lincosamides
  • Severe diarrhea
    • History of Clostridium difficile-associated diarrhea
    • Crohn's disease
    • Ulcerative colitis
    • Regional enteritis
  • Weakened condoms and vaginal diaphragms
  • Safety in girls who haven't started puberty
See more detailed risks and warnings
No information currently available
Learn more about Clindesse (clindamycin)
Learn more about Lotrimin (Clotrimazole)