Compare clobetasol vs. Locoid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps with inflamed and itchy skin.

Clobex (clobetasol) is a very strong topical medication that is effective for treating certain skin disorders and psoriasis, but it's expensive and should only be used for a maximum of 2 weeks at a time.

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Upsides
  • Clobex (clobetasol) is the strongest topical steroid medicine available in the U.S. and is effective for treating skin inflammation and psoriasis.
  • Clobex (clobetasol) comes in many different forms that makes it easy to use on various parts of the body.
  • If Clobex (clobetasol) is applied sparingly and not used for more than 2 weeks at a time, there are fewer side effects compared to the oral version.
  • Pregnant women can use Clobex (clobetasol) if approved by their doctor.
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Downsides
  • Using Clobex (clobetasol) for more than 2 weeks at a time can cause side effects such as skin thinning and raised blood sugar.
  • Clobex (clobetasol) is expensive and not covered by many insurance programs.
  • Clobex (clobetasol) is not safe for use on areas of the face, underarms or groin.
  • Not safe for children 12 years and younger.
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Used for
Dosage forms
  • Cream
  • Foam
  • Gel
  • Liquid
  • Lotion
  • Shampoo
  • Solution
  • Emollient cream
  • Cream, gel, or ointment
  • Topical
Price
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Reviews
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Side effects
The Clobex (clobetasol) FDA package insert doesn’t have numbers about how common side effects are.
The Locoid (Hydrocortisone Butyrate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Skin irritation and skin infection
    • Open sores
  • Skin thinning
    • People age 65 and older
  • Raised blood sugar
    • Using Clobex (clobetasol) for more than 2 weeks
    • Using Clobex (clobetasol) over large areas of skin
See more detailed risks and warnings
No information currently available