Compare Clotrimazole vs. Itraconazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats fungal infections.

Sporanox (itraconazole) is effective oral medication that treats many different kinds of fungal infections. However, it has the potential to interact with a lot of other medications and has a few serious but rare side effects.

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  • Sporanox (itraconazole) is effective in treating infections caused by many different types of fungi.
  • Available as a generic in the capsule form.
  • Sporanox (itraconazole) can be used by people who have kidney problems.
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  • The liquid solution is especially likely to cause stomach upset like nausea and diarrhea.
  • Sporanox (itraconazole) is not a good choice for simple fungal infections (like nail infections) in people who have congestive heart failure because it can cause high blood pressure and swelling of the limbs.
  • Sporanox (itraconazole) isn't absorbed in the same way by everyone. You'll likely need to get lab tests done to check on its levels in the blood.
  • Sporanox (itraconazole) can cause serious side effects like allergic reactions, liver toxicity, nerve pain, or hearing loss.
  • Sporanox (itraconazole) has a lot of drug interactions. Let your doctor or pharmacist know about all of the medications you're taking.
Used for
  • Candidal vulvovaginitis Candidiasis
  • Topical Oropharyngeal candidiasis Oropharyngeal candidiasis; Prophylaxis Pityriasis versicolor Tinea corporis Tinea cruris Tinea pedis
  • Candidal vulvovaginitis
  • Recurrent; Prophylaxis
  • Salvage therapy for invasive aspergillosis
  • Blastomycosis
  • Oropharyngeal and esophageal candidiasis
  • Histoplasmosis
  • Onychomycosis
  • Vulvovaginal candidiasis in HIV-infected patients
  • Coccidioidal meningitis in HIV-infected patients
  • Coccidioidal pneumonia in HIV-infected patients
  • Cryptococcosis in HIV-infected patients
  • Disseminated microsporidiosis in HIV-infected patients
  • Penicilliosis in HIV-infected patients
Dosage forms
  • Cream, gel, or ointment
  • Topical
  • Spray
  • Topical
  • Lozenge
  • Pill
  • Liquid
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Side effects
The Lotrimin (Clotrimazole) FDA package insert doesn’t have numbers about how common side effects are.
14possible side effects
  • Nausea
  • Rash
  • Vomiting
  • Swelling due to fluid retention
  • Headache
  • Diarrhea
  • Tiredness
  • Fever
  • Itching
  • High blood pressure
  • Lowered liver function
  • Abdominal pain
  • Dizziness
  • Low potassium
See more detailed side effects
Risks and risk factors
No information currently available
  • Congestive Heart Failure
    • History of congestive heart failure
  • Drug interactions
  • Liver toxicity
  • Irregular heartbeat
    • Taking other medications that can produce an irregular heartbeat
  • Do not switch between the capsules or liquid forms
See more detailed risks and warnings