Compare Clozaril vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Clozaril (clozapine)

Prescription only

Seroquel (quetiapine)

Prescription only
Helps control your thoughts and actions.

Clozaril (clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get regular blood work done because it can have very serious side effects.

Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

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3.7/ 5 average rating with 250 reviewsforSeroquel
Upsides
  • Studies show that Clozaril (clozapine) effectively treats schizophrenia when other medications have failed. Clozaril (clozapine) also reduces risk of suicidal behavior.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Safer than other similar medicines during pregnancy.
  • Available as a generic, which is cheaper.
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides
  • You need to get blood work done every time you get a prescription filled for Clozaril (clozapine). Once it is ready at the pharmacy, you need to pick it up within 7 days.
  • You can only get Clozaril (clozapine) at certain pharmacies that are registered to provide it.
  • You need to limit the amount of alcohol you drink while taking Clozaril (clozapine).
  • Clozaril (clozapine) can cause high blood sugar, high cholesterol, and weight gain.
  • May not be optimal for someone with a history of seizures.
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
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Used for
  • Schizophrenia
  • Suicidal behavior in schizophrenia
  • Psychosis in Parkinson's disease
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Extended release
Price
Lowest price
$766.92
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Lowest price
$20.79
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Reviews
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250 reviews so far
56%
saidit'sworth it
50%
saiditworked well
27%
saidit'sa big hassle

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Side effects
31possible side effects
  • Drowsiness/sedation
    39%
  • Salivation
    31%
  • Fast heartbeat
    25%
  • Dizziness/vertigo
    19%
  • Constipation
    14%
  • Low blood pressure
    9%
  • Headache
    7%
  • Tremor
    6%
  • Fainting
    6%
  • Sweating
    6%
  • Dry mouth
    6%
  • Nausea
    5%
  • Vision problems
    5%
  • Fever
    5%
  • Disturbed sleep/nightmares
    4%
  • Restlessness
    4%
  • Loss of muscle movement
    4%
  • Agitation
    4%
  • High blood pressure
    4%
  • Stomach discomfort/heartburn
    4%
  • Weight gain
    4%
  • Seizures (convulsions)
    3%
  • Rigidity
    3%
  • Confusion
    3%
  • Nausea/vomiting
    3%
  • Low white blood cells
    3%
  • Fatigue
    2%
  • Trouble sleeping
    2%
  • Diarrhea
    2%
  • Problems urinating
    2%
  • Rash
    2%
See more detailed side effects
36possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
  • Weight gain
    6%
  • Sore throat
    6%
  • Back pain
    5%
  • Stiffness/difficulty moving
    4%
  • Hay fever
    4%
  • Swelling in the limbs
    4%
  • Twitching
    4%
  • Indigestion
    4%
  • Depression
    3%
  • Lazy eye
    3%
  • Speech disorder
    3%
  • Altered hormone levels
    3%
  • Heaviness
    2%
  • Infection
    2%
  • Fever
    2%
  • High blood pressure
    2%
  • Increased heart rate
    2%
  • Increased appetite
    2%
  • Hypothyroidism
    2%
  • Incoordination
    2%
  • Abnormal thinking
    2%
  • Anxiety
    2%
  • Loss of control of movements
    2%
  • Sinus infection
    2%
  • Sweating
    2%
  • Urinary Tract Infection
    2%
See more detailed side effects
Risks and risk factors
  • Low white blood cells
  • Low blood pressure, slow heartbeat, and fainting
    • Dehydration
    • Taking blood pressure medications
    • Heart failure
  • Seizures
    • Seizure disorder
    • Alcohol abuse
  • Heart problems
    • History of heart problems
  • Increased risk of death in elderly with dementia
    • Over 65 with dementia
  • High blood sugar, high cholesterol, and weight gain
See more detailed risks and warnings
  • Higher risk of death
    • Elderly patients with dementia-related psychosis
  • Suicidal thoughts or behavior
    • Children, adolescents, and young adults (<24 years old)
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Extrapyramidal Symptoms (EPS)
  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
Learn more about Clozaril (clozapine)
Learn more about Seroquel (quetiapine)