Compare Clozaril vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Clozaril (Clozapine)

Prescription only

Zyprexa (olanzapine)

Prescription only
Helps control your thoughts and actions.

Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.

Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

3.7/ 5 average rating with 68 reviewsforZyprexa
Upsides
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
Downsides
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Injection
Price
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Reviews
Not enough review data.Leave a review
68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle

Have you used Zyprexa (olanzapine)?

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Side effects
33possible side effects
  • Drowsiness/Sedation
    39%
  • Salivation
    31%
  • Tachycardia
    25%
  • Dizziness/Vertigo
    19%
  • Constipation
    14%
  • Hypotension
    9%
  • Headache
    7%
  • Tremor
    6%
  • Syncope
    6%
  • Sweating
    6%
  • Dry Mouth
    6%
  • Nausea
    5%
  • Visual Disturbances
    5%
  • Fever
    5%
  • Disturbed Sleep/Nightmares
    4%
  • Restlessness
    4%
  • Hypokinesia/Akinesia
    4%
  • Agitation
    4%
  • Hypertension
    4%
  • Abdominal Discomfort/Heartburn
    4%
  • Weight Gain
    4%
  • Seizures (convulsions)
    3%
  • Rigidity
    3%
  • Akathisia
    3%
  • Confusion
    3%
  • Nausea/Vomiting
    3%
  • Vomiting
    3%
  • Leukopenia/Decreased WBC/Neutropenia
    3%
  • Fatigue
    2%
  • Insomnia
    2%
  • Diarrhea
    2%
  • Urinary Abnormalities
    2%
  • Rash
    2%
See more detailed side effects
9possible side effects
  • Drowsiness
    48%
  • Weight gain
    28%
  • Increased appetite
    28%
  • Headache
    17%
  • Fatigue
    14%
  • Dizziness
    7%
  • Dry Mouth
    7%
  • Abdominal pain
    6%
  • Pain in extremity
    5%
See more detailed side effects
Risks and risk factors
  • Fewer white blood cells
  • Low blood pressure | Slow heartbeat | Fainting
    • Dehydration
    • Taking blood pressure medications
  • Seizures
    • Seizure disorder
    • Alcohol abuse
  • Heart problems
    • History of heart problems
  • Increased risk of death
    • Over 65 and having dementia
  • Weight gain
  • Increased blood sugar
    • Diabetes
  • Increased cholesterol
  • Neuroleptic malignant syndrome (NMS)
  • Tardive dyskinesia
  • Return of schizophrenic symptoms
    • Stopping Clozaril (Clozapine) suddenly
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar, high cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings