Compare Cogentin vs. Artane

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats Parkinson's disease.

Good for treating tremors caused by Parkinson's and for treating uncontrolled movements in people taking antipsychotics.

Treats Parkinson's disease.

Artane (trihexyphenidyl) can be used to control tremors if you have Parkinson's, but it can really dry you out and cause other side effects.

Upsides
  • Cogentin (benztropine) can be used with other medicines for people with more advanced Parkinson's who continue to have tremors.
  • Works by itself in people under 65 who only have Parkinson's tremors and not other symptoms.
  • Can be used in people who have movement problems because they're taking antipsychotic drugs.
  • Available as generic.
  • Artane (trihexyphenidyl) can be used with other medicines and in people with advanced Parkinson's who still have tremors.
  • Effective by itself for people under 70 with Parkinson's who only have problems with tremors.
  • Less severe side effects compared to other medicines for tremors.
  • Available as generic.
Downsides
  • Only treats the tremors in Parkinson's and not the other symptoms.
  • Not recommended in people over 65 or those with memory difficulties or problems thinking clearly because they're more likely to have confusion with Cogentin (benztropine).
  • Can't be used in people who have glaucoma.
  • Not recommended in people over 65 or in people with memory problems.
  • Artane (trihexyphenidyl) only calms down tremors because of Parkinson's, but it doesn't treat other symptoms.
  • Can't be used in people with glaucoma or an enlarged prostate.
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Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Liquid
Price
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Reviews
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Side effects
The Cogentin (benztropine) FDA package insert doesn’t have numbers about how common side effects are.
The Artane (trihexyphenidyl) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Intestinal paralysis
    • Taking tricyclic antidepressants
    • Taking phenothiazines or haloperidol
  • Weakness
  • Dehydration
    • Over age 65
    • Dehydration
  • Heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Memory problems and confusion
    • Over age 65
    • History of mental or psychiatric conditions
See more detailed risks and warnings
  • Neuroleptic malignant syndrome
    • Abruptly stopping Artane (trihexyphenidyl)
  • Drowsiness and dizziness
  • Vision problems
    • Narrow angle glaucoma
  • Dehydration
    • Over age 65
  • Fever and heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Psychiatric problems
    • Over age 65
    • History of mental or psychiatric problems
See more detailed risks and warnings