Compare Cogentin vs. carbidopa / levodopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats Parkinson's disease.

Good for treating tremors caused by Parkinson's and for treating uncontrolled movements in people taking antipsychotics.

Treats Parkinson's disease.

Sinemet (carbidopa / levodopa) is the first choice treatment for Parkinson's disease.

Upsides
  • Cogentin (benztropine) can be used with other medicines for people with more advanced Parkinson's who continue to have tremors.
  • Works by itself in people under 65 who only have Parkinson's tremors and not other symptoms.
  • Can be used in people who have movement problems because they're taking antipsychotic drugs.
  • Available as generic.
  • Sinemet (carbidopa / levodopa) is widely available as a regular pill, a quick dissolving pill or a liquid taken through a feeding tube.
  • Sinemet (carbidopa / levodopa) is available in generic.
Downsides
  • Only treats the tremors in Parkinson's and not the other symptoms.
  • Not recommended in people over 65 or those with memory difficulties or problems thinking clearly because they're more likely to have confusion with Cogentin (benztropine).
  • Can't be used in people who have glaucoma.
  • Can make you very sleepy.
  • Can stain your saliva, sweat and urine a dark color.
  • Will lose its effect over time as your disease progresses.
  • May need to be taken several times during day to control symptoms of Parkinson's disease
  • May cause unusual cravings in some people.
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Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
Price
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Reviews
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Side effects
The Cogentin (benztropine) FDA package insert doesn’t have numbers about how common side effects are.
The Sinemet (carbidopa / levodopa) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Intestinal paralysis
    • Taking tricyclic antidepressants
    • Taking phenothiazines or haloperidol
  • Weakness
  • Dehydration
    • Over age 65
    • Dehydration
  • Heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Memory problems and confusion
    • Over age 65
    • History of mental or psychiatric conditions
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Sinemet (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Changes in blood pressure and falls
See more detailed risks and warnings