Compare Cogentin vs. Eldepryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats Parkinson's disease.

Good for treating tremors caused by Parkinson's and for treating uncontrolled movements in people taking antipsychotics.

Treats Parkinson's disease.

Used with other medicines for Parkinson's disease to boost its effect.

  • Cogentin (benztropine) can be used with other medicines for people with more advanced Parkinson's who continue to have tremors.
  • Works by itself in people under 65 who only have Parkinson's tremors and not other symptoms.
  • Can be used in people who have movement problems because they're taking antipsychotic drugs.
  • Available as generic.
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Only treats the tremors in Parkinson's and not the other symptoms.
  • Not recommended in people over 65 or those with memory difficulties or problems thinking clearly because they're more likely to have confusion with Cogentin (benztropine).
  • Can't be used in people who have glaucoma.
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
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Side effects
The Cogentin (benztropine) FDA package insert doesn’t have numbers about how common side effects are.
11possible side effects
  • Skin irritation at the patch
  • Headache
  • Insomnia
  • Diarrhea
  • Dry mouth
  • Weight loss of at least 5%
  • Indigestion
  • Rash
  • Sore throat
  • Sinus infection
  • Weight gain of at least 5%
See more detailed side effects
Risks and risk factors
  • Intestinal paralysis
    • Taking tricyclic antidepressants
    • Taking phenothiazines or haloperidol
  • Weakness
  • Dehydration
    • Over age 65
    • Dehydration
  • Heat stroke
    • Dehydration
    • Prolonged exposure to hot conditions
    • Alcohol
    • Manual laborers
  • Memory problems and confusion
    • Over age 65
    • History of mental or psychiatric conditions
See more detailed risks and warnings
  • Increased blood pressure
    • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
    • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Increased risk of skin cancer
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Low blood pressure
See more detailed risks and warnings