Compare Colcrys vs. Benemid

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Colcrys (colchicine)

Prescription only

Benemid (probenecid)

Prescription only
Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Lowers uric acid levels and strengthens penicillin's effect.

Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.

  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
  • Benemid (probenecid) is available in generic.
  • It can raise levels of certain antibiotics in the body and make those antibiotics work better.
  • It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
  • Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
  • It doesn't work well in people who are using aspirin, or have kidney problems.
  • You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
5possible side effects
  • Stomach problems
  • Diarrhea
  • Nausea
  • Gout
  • Throat pain
See more detailed side effects
The Benemid (probenecid) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood disorders
  • Death from overdose
  • Food and medicine interactions
    • Grapefruit
    • Grapefruit juice
    • Protease inhibitors
    • Antifungal antibiotics
    • Calcium channel blockers
    • Cyclosporine
    • Anti-cholesterol medicines
    • Digoxin
  • Muscle pain and breakdown
    • Kidney problems
    • Elderly
    • Use of statins or cholesterol medications
    • Use of cyclosporine
See more detailed risks and warnings
  • Kidney stones
  • Blood disorders
    • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Gout attacks
    • Taking Benemid (probenecid) for the first few weeks
  • Kidney problems
    • History of kidney problems
  • Stomach ulcers
    • History of esophagus or stomach problems, including ulcers
See more detailed risks and warnings