Compare Colcrys vs. Uloric

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Colcrys (colchicine)

Prescription only

Uloric (febuxostat)

Prescription only
Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Stops gout attacks.

Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.

  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
  • Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
  • You only need to take Uloric (febuxostat) once a day.
  • People with mild to moderate kidney disease can use Uloric (febuxostat).
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
  • You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
  • While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
  • You'll have to get your blood checked often with Uloric (febuxostat) therapy.
  • Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
5possible side effects
  • Stomach problems
  • Diarrhea
  • Nausea
  • Gout
  • Throat pain
See more detailed side effects
The Uloric (febuxostat) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood disorders
  • Death from overdose
  • Food and medicine interactions
    • Grapefruit
    • Grapefruit juice
    • Protease inhibitors
    • Antifungal antibiotics
    • Calcium channel blockers
    • Cyclosporine
    • Anti-cholesterol medicines
    • Digoxin
  • Muscle pain and breakdown
    • Kidney problems
    • Elderly
    • Use of statins or cholesterol medications
    • Use of cyclosporine
See more detailed risks and warnings
  • Gout flare-ups
  • Blood clots
    • History of stroke or heart attack
  • Liver problems
  • Allergic reaction
    • History of skin reaction to allopurinol
See more detailed risks and warnings