Compare Combipatch vs. Estrogel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats low estrogen and relieves menopause symptoms.

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

Relieves hot flashes and vaginal dryness due to menopause.

Estrogel (Estradiol) is a topical gel that can relieve both vaginal dryness and hot flashes, but needs to be applied across the length your entire arm.

3.2/ 5 average rating with 78 reviewsforEstrogel
Upsides
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
  • The pump is easy to use and comes in two different bottle sizes.
  • Good alternative if you don't want to take estrogen pills.
Downsides
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
  • Available as brand name product only so it may be expensive.
  • Directions for application can be messy and hard to follow.
  • You may unknowingly expose others to the medicine through skin contact.
  • All estrogen replacement therapies are associated with serious side-effects like blood clots, uterine cancer, and breast cancer. You will need to thoroughly discuss the risks and benefits with your doctor before starting treatment.
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Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
Dosage forms
  • Patch
  • Gel
Price
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Reviews
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78 reviews so far
45%
saidit'sworth it
28%
saiditworked well
10%
saidit'sa big hassle

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Side effects
24possible side effects
  • Breast pain
    25%
  • Menstrual cramps
    20%
  • Headache
    18%
  • Back pain
    11%
  • Nausea
    11%
  • Flu like symptoms
    9%
  • Weakness
    8%
  • Abnormal pap smear
    8%
  • Stomach pain
    7%
  • Lung problems
    7%
  • Stuffy nose
    7%
  • Pain
    6%
  • Menstrual problems
    6%
  • Vaginal inflammation
    6%
  • Vaginal discharge
    5%
  • Accidental injury
    4%
  • Diarrhea
    4%
  • Gas
    4%
  • Sore throat
    4%
  • Sinus infection
    4%
  • Depression
    3%
  • Trouble sleeping
    3%
  • Nervousness
    3%
  • Skin irritation
    2%
See more detailed side effects
3possible side effects
  • Breast pain
    11%
  • Headache
    10%
  • Gas
    5%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Dementia
    • Aged 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
  • Gallbladder problems
See more detailed risks and warnings
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings