Compare Combivent vs. Spiriva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Makes it easier to breathe.

Combivent (ipratropium / albuterol) is effective for people who need 2 medications to control their COPD symptoms, but has to be used 4 times a day.

3.4/ 5 average rating with 142 reviewsforCombivent
Makes it easier to breathe.

Spiriva (Tiotropium) works well to reduce COPD symptoms and flare-ups with fewer side effects than some medicines that open airways, but you have to use it every day.

3.5/ 5 average rating with 74 reviewsforSpiriva
Upsides
  • Effectively relieves symptoms of COPD.
  • The Respimat inhaler doesn't require shaking before use, and only 1 inhalation per dose is needed.
  • The nebulizer solution comes in a generic form and is much cheaper than the inhaler.
  • Helps you breathe easier and lessens the need for a fast-acting (rescue) inhaler.
  • Reduces flare-ups and hospitalizations with fewer side effects compared to some other medicines that open airways.
  • You only need to take it once a day.
Downsides
  • No generic form of the inhaler is currently available, so it can be very expensive for people without insurance.
  • Can make your heart beat faster, which is an uncomfortable side effect. Might not be a good option for those with heart problems since the medicine can raise your heart rate and blood pressure.
  • Can raise eye pressure and worsen symptoms for people who have a certain type of glaucoma.
  • Can cause problems with urinating, so might not be appropriate for those with an enlarged prostate.
  • Won't cure your COPD (but it will relieve your symptoms).
  • You'll need to use this medicine for a long time, and you have to take it every day.
  • Can make symptoms of enlarged prostate or urinary blockage worse.
  • Can worsen a certain type of glaucoma.
  • You might feel dizzy or have blurry vision while taking this medicine.
ADVERTISEMENT
Used for
Dosage forms
  • Inhaler
  • Nebulizer solution
  • Inhaler
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
142 reviews so far
63%
saidit'sworth it
37%
saiditworked well
13%
saidit'sa big hassle

Have you used Combivent (ipratropium / albuterol)?

Leave a review
74 reviews so far
64%
saidit'sworth it
46%
saiditworked well
8%
saidit'sa big hassle

Have you used Spiriva (Tiotropium)?

Leave a review
Side effects
11possible side effects
  • Lung disease
    6%
  • Common cold symptoms
    4%
  • Sore throat
    4%
  • Cough
    3%
  • Headache
    3%
  • Inflammation of lung airways
    3%
  • Infection of airways, nose, and throat
    3%
  • Chest pain
    3%
  • Shortness of breath
    2%
  • Diarrhea
    2%
  • Urinary tract infection
    2%
See more detailed side effects
36possible side effects
  • Respiratory tract Infection
    41%
  • Dry mouth
    16%
  • Pharyngitis
    13%
  • Sinusitis
    11%
  • Chest pain (non-specific)
    7%
  • Urinary tract Infection
    7%
  • Dyspepsia
    6%
  • Rhinitis
    6%
  • Headache
    6%
  • Edema, Dependent
    5%
  • Abdominal pain
    5%
  • Constipation
    5%
  • Dry Mouth
    5%
  • Vomiting
    4%
  • Myalgia
    4%
  • Infection
    4%
  • Moniliasis
    4%
  • Epistaxis
    4%
  • Rash
    4%
  • Depression
    4%
  • Insomnia
    4%
  • Arthralgia
    4%
  • Allergic reaction
    3%
  • Leg pain
    3%
  • Dysphonia
    3%
  • Parathesia
    3%
  • Gastroinestinal disorder not otherwise specified
    3%
  • Castroesophegeal reflux
    3%
  • Stomatitis
    3%
  • Hypercholesterolemia
    3%
  • Hyperglycemia
    3%
  • Skeletal pain
    3%
  • Angina pectoris
    3%
  • Herpes zoster
    3%
  • Laryngitis
    3%
  • Cataract
    3%
See more detailed side effects
Risks and risk factors
  • Sudden-onset difficulty breathing
  • Effects on heart
    • Using more Combivent (ipratropium / albuterol) than recommended
    • People with heart problems
    • People with high blood pressure
    • People with an overactive thyroid
  • Effects on eyes
    • People with a history of narrow-angle glaucoma
  • Difficulty urinating
    • People with a history of urinary blockage
    • People with an enlarged prostate
  • Severe allergic reaction
  • Life-threatening effects
    • Using more Combivent (ipratropium / albuterol) than recommended
See more detailed risks and warnings
  • Serious allergic reaction
    • History of atropine allergic reaction
  • Sudden onset difficulty breathing (paradoxical bronchospasm)
  • Worsening glaucoma
    • History of narrow-angle glaucoma
  • Difficulty urinating
    • History of urinary bladder blockage (urinary obstruction)
    • History of enlarged prostate
  • Serious allergic reaction
    • Severe milk protein allergy
  • Reduced kidney function
    • History of moderate to severe kidney disease
  • Feeling dizzy
    • Taking with other anticholinergic medications
See more detailed risks and warnings