Compare Compro vs. Aloxi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Compro (Prochlorperazine)

Prescription only

Aloxi (palonosetron)

Prescription only
Helps you feel less queasy.

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.

3.0/ 5 average rating with 20 reviewsforCompro
Stops nausea caused by chemotherapy or surgery.

Aloxi (palonosetron) is given one time to effectively reduce nausea from chemotherapy or surgery. In some cases, it will only help for a short period of time.

Upsides
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
  • Aloxi (palonosetron) can be given through the same IV line as your chemotherapy - as a one-time dose 30 minutes before treatment starts.
  • Starts working in 30 minutes.
  • Aloxi (palonosetron) can be used in children as young as 1 month of age.
Downsides
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
  • If your chemotherapy is very likely to make you feel queasy or if you have nausea after surgery, Aloxi (palonosetron) is usually only helpful for one day.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
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Used for
  • Nausea and vomiting from chemotherapy or surgery
Dosage forms
  • Pill
  • Suppository
  • Injection
Price
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Reviews
20 reviews so far
45%
saidit'sworth it
35%
saiditworked well
35%
saidit'sa big hassle

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Side effects
The Compro (Prochlorperazine) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Abnormal heartbeat
    5%
  • Slow heart rate
    4%
  • Headache
    3%
  • Constipation
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Over age 65
    • Dementia
    • Taking antipsychotics
  • Seizures
    • History of seizures
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
  • Heatstroke
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking antidepressants, lithium, some migraine medications, and St. John's wort.
  • Severe allergic reaction
See more detailed risks and warnings